المشاكس
07-30-2008, 08:28 AM
التركيبات الصيدلانية...
خطوة بخطوة ,,
INTRODUCTION OF ORAL LIQUID DOSAGE FORMS
- why pharmacist should compound oral dosage forms
1 - Many drug products are not commercially available as oral liquid
مثال: عند نقص دواءالـBuscopan syrup من السوق كان لابد من ايجاد طريقة اخرى
لتحضيرة فى هيئة سائل من اجل الاطفال
2- Infants, pediatric, and some psychiatric patients cannot swallow solid dosage forms.
3- Drugs are often more bioavailable in liquid form than solid form
*difficulties facing pharmacist who is going to prepare an oral liquid dosage forms:
- unstable drugs are even more unstable in solution. - Poorly soluble drugs must be solublised or suspended. - Bad tasting drugs must be flavored to be relatively platable. - Multiple dose packages need a proper preservation system
.
وهذه احدى المشاكل التى تواجهنا عندما نحضر السوائل
لذلك هناك احتياطات يجب اتخاذها لتقليل هذة المشاكل وتفاديها
وتحسين خواص التركيبة ومنها:
1- The source of active ingredients:
the pharmaceutical or analytical grade chemicals are better for use rather than ones derived from commercially available drug like injection, tablets, or capsules
يجب تحرى الدقة فى المصدر الذى نحصل منه على المواد الخام
لانها تكون افضل من التى نحصل عليها من الحقن او الاقراص والكبسولات.
2- Sustained acting or slow release tablets or capsules are not suitable for use as a source of the active ingredients.
لايصح استعمال الاقراص اوالكبسولات ممتدة المفعول او بطيئة المفعول فى تحضيرالسوائل
3- Physicochemical properties of the active ingradients, pH of maximum stability and solubility may be greatly influence the quality and the activity of pharmaceutical dosage form
* PH is critical in maintaining drug in solution, a slight inc. or dec. in the pH
can cause some drugs to precipitate from a solution
.
-a slight adjustment of PH can aid in solubilising some drugs.
N.B: Basic drugs are highly soluble in acidic medium and vice versa
Stability and storage condition of preparation
:
N.B:-liquids for oral use may contain suitable antimicrobial preservative, antioxidants, and other exepients such as dispersing, suspending, thickening, emulsifying, buffering, wetting, solubilising, flavoring, sweetening and coloring agents.
والمواد المضافة هذه هدفها هى تحسين خواص السائل للوصول الى الشكل المرغوب فية من حيث الخواص والطعم والشكل .......الخ
- Storage Oral liquids should be stored in well closed containers.
Labeling :
the label should states
:
1- The date after which the oral liquid is not intended to be used
.
يجب ان ندون تاريخ الصلاحية.
2- The conditions under which the oral
liquid should be stored
شروط التخزين للدواء مثل درجة الحرارة....الخ
3- For oral emulsions, oral suspensions……etc
the bottle should be shaken before use
اخوكم
رائد
خطوة بخطوة ,,
INTRODUCTION OF ORAL LIQUID DOSAGE FORMS
- why pharmacist should compound oral dosage forms
1 - Many drug products are not commercially available as oral liquid
مثال: عند نقص دواءالـBuscopan syrup من السوق كان لابد من ايجاد طريقة اخرى
لتحضيرة فى هيئة سائل من اجل الاطفال
2- Infants, pediatric, and some psychiatric patients cannot swallow solid dosage forms.
3- Drugs are often more bioavailable in liquid form than solid form
*difficulties facing pharmacist who is going to prepare an oral liquid dosage forms:
- unstable drugs are even more unstable in solution. - Poorly soluble drugs must be solublised or suspended. - Bad tasting drugs must be flavored to be relatively platable. - Multiple dose packages need a proper preservation system
.
وهذه احدى المشاكل التى تواجهنا عندما نحضر السوائل
لذلك هناك احتياطات يجب اتخاذها لتقليل هذة المشاكل وتفاديها
وتحسين خواص التركيبة ومنها:
1- The source of active ingredients:
the pharmaceutical or analytical grade chemicals are better for use rather than ones derived from commercially available drug like injection, tablets, or capsules
يجب تحرى الدقة فى المصدر الذى نحصل منه على المواد الخام
لانها تكون افضل من التى نحصل عليها من الحقن او الاقراص والكبسولات.
2- Sustained acting or slow release tablets or capsules are not suitable for use as a source of the active ingredients.
لايصح استعمال الاقراص اوالكبسولات ممتدة المفعول او بطيئة المفعول فى تحضيرالسوائل
3- Physicochemical properties of the active ingradients, pH of maximum stability and solubility may be greatly influence the quality and the activity of pharmaceutical dosage form
* PH is critical in maintaining drug in solution, a slight inc. or dec. in the pH
can cause some drugs to precipitate from a solution
.
-a slight adjustment of PH can aid in solubilising some drugs.
N.B: Basic drugs are highly soluble in acidic medium and vice versa
Stability and storage condition of preparation
:
N.B:-liquids for oral use may contain suitable antimicrobial preservative, antioxidants, and other exepients such as dispersing, suspending, thickening, emulsifying, buffering, wetting, solubilising, flavoring, sweetening and coloring agents.
والمواد المضافة هذه هدفها هى تحسين خواص السائل للوصول الى الشكل المرغوب فية من حيث الخواص والطعم والشكل .......الخ
- Storage Oral liquids should be stored in well closed containers.
Labeling :
the label should states
:
1- The date after which the oral liquid is not intended to be used
.
يجب ان ندون تاريخ الصلاحية.
2- The conditions under which the oral
liquid should be stored
شروط التخزين للدواء مثل درجة الحرارة....الخ
3- For oral emulsions, oral suspensions……etc
the bottle should be shaken before use
اخوكم
رائد